Marijuana use has long been associated with the “munchie” phenomenon and now a mouse study may shed light on why. Hyperphagia, or over eating, after getting high is due to certain cells in the hypothalmus called  pro-opiomelanocortin (POMC) neurons that activate melanocyte stimulating hormone (a-MSH) that generates feelings of fullness. When POMC neurons are manipulated in any way, the a-MSH receptors get blocked and people (and mice) are headed to the pantry. While there is much more to study on this subject, like what mechanisism causes an appetite suppressant neuron to become an appetite simulator, it gives rise to possible hope for obesity treatments? Or at the very least a lower grocery bill for some. Click below to read more on this amazing science and pathway. 

http://www.the-scientist.com/?articles.view/articleNo/42188/title/Neuroscience-of-Marijuana-Munchies/

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