Using a broader design, researchers have a new target for epilepsy treatment. Studying individual genes has long been the approach to understanding epilepsy but pulling back, scientists identified a gene network that was highly active in the brain of epileptic patients, and then discovered that an unconnected gene, Sestrin 3 (SESN3), acts as a regulator of this epileptic gene network. This is the first time this gene has been identified in epilepsy and the findings were confirmed in zebra fish and mice. 

Patients who do not respond to medication can actually have this portion of the brain removed to alleviate seizures and now that the gene SESN3 has been identified hopefully new therapies can be developed.

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