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Therapies & Treatments – Helping Patients Live Better Lives

Heart Disease
Sometimes heart disease may be “silent” and not diagnosed until a person experiences signs or symptoms of a heart attack, heart failure, or an arrhythmia. (Photo credit: fotostorm /  E+ / Getty Images)
(Photo credit: fotostorm / E+ / Getty Images)

The term “heart disease” refers to several types of heart conditions. The most common type of heart disease in the United States is coronary artery disease (CAD), which affects the blood flow to the heart. Decreased blood flow can cause a heart attack. Sometimes heart disease may be “silent” and not diagnosed until a person experiences signs or symptoms of a heart attack, heart failure or an arrhythmia. Common risk factors for heart disease include high blood pressure, high LDL (low-density lipoprotein) cholesterol, low potassium levels and diabetes (which we explore in the next section).

Patient Stories 
Caring for someone with heart failure: https://www.novartis.com/stories/patient-perspectives/caring-someone-heart-failure
Cynthia – Living with heart failure: https://www.novartis.com/stories/patient-perspectives/living-with-hfpef-patient-story
Heart failure: coping with one of the world’s biggest killers:https://www.novartis.com/stories/patient-perspectives/heart-failure-coping-one-worlds-biggest-killers
A personal story about Atrial Fibrillation detection: https://www.bms.com/life-and-science/news-and-perspectives/afib-signs-symptoms-and-stroke-risk.html
Heart disease, family health history, and Familial Hypercholesterolemia (FH):https://www.cdc.gov/genomics/disease/fh/personal_stories.htm

Examples of Common Treatments Developed With Animal Models

DrugUsageAnimal Models
AmlodipineHigh blood pressure, chest painCats, dogs, hamsters, guinea pigs, mice, rats, monkeys, pigs, rabbits
ApixabanBlood clots, stroke in people with arrhythmiaMice, monkeys, rats, rabbits
AspirinReduces risks of heart attackHamsters, cats, dogs, mice, monkeys, pigs, rabbits, rats, zebrafish
AtenololHigh blood pressure, chest pain, uneven heartbeatHamsters, mice, monkeys, rabbits, rats
AtorvastatinHigh cholesterol and triglyceride levelsDogs, guinea pigs, hamsters, mice, rats, monkeys, pigs, rabbits, zebrafish
Clopidogrel BisulfatePrevent stroke, heart attack and other heart problemsHamsters, mice, monkeys, rabbits, rats
Furosemide"Water pill," fluid retention from heart failure, liver and kidney disease, high blood pressureCats, dogs, hamsters, guinea pigs, mice, rats, monkeys, pigs, rabbits, zebrafish
HydrochlorothiazideHigh blood pressure, fluid retentionDogs, guinea pigs, mice, rats, monkeys
LisinoprilHigh blood pressure, heart failureDogs, guinea pigs, hamsters, mice, rats, monkeys, rabbits
Losartan PotassiumHigh blood pressure Mice, rats, monkeys, rabbits, sheep
MetoprololHigh blood pressure, chest pain, heart failureCats, dogs, guinea pigs, mice, rats, monkeys, rabbits, frogs
Pravastatin SodiumHigh cholesterolCats, dogs, hamsters, mice, rats, monkeys, pigs, rabbits, zebrafish
Propranolol HydrochlorideHigh blood pressure, fluid retention, high levels of the hormone aldosterone (which can cause high blood pressure and low potassium levels, both of which are heart disease risk factors)Dogs, guinea pigs, mice, monkeys, rabbits, rats
RosuvastatinHigh cholesterol and triglyceride levelsMice, monkeys, rabbits, rats
SimvastatinHigh cholesterol and triglyceride levelsDogs, hamsters, guinea pigs, mice, rats, monkeys, pigs, rabbits, zebrafish
WarfarinBlood clotsMice, hamsters, monkeys, rabbits, rats
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